I have been using this product, along with the Enzymatic Rinse for about two years now. It is the best product ever, believe me, I had bottles and bottles of everything available on the market, for my cocker spaniel who has skin issues, especially during the summer. This shampoo when used with the rinse helps to relieve his itching and "hot spots". It is safe and very gentle to use as often as needed. I also use the rinse (diluted, in a spray bottle) on the days he is not getting a bath to help calm him from itching...this shampoo and rinse by Zymox is the best, you will find nothing on the market like it. It is much more reasonable when purchased online, than from your vet. Dog has skin issues, this product will literally help and heal!