How does Denosyl work?

Denosyl has been shown to markedly increase liver levels of glutathione,^1,2 an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized.

Denosyl has also been shown to help protect liver cells from cell death^3,4 and may help cell repair and regeneration.⁵

While best known for supporting the liver in dogs and cats Denosyl also has a place in supportingbrain health! Denosyl could help your best friend live a longer, healthier life.

Research is looking into dog aging and associated decreases in levels of SAMe (S-Adenosylmethionine) in cerebrospinal fluid, which surrounds the brain. Denosyl provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

The new chewable tablets of Denosyl allow dogs to receive SAMe in a tasty treat eliminating the need to "pill" your dog daily. Additionally, the chewable tablets are absorbed more quickly when compared to hard enteric-coated tablets.

Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. Studies have shown that, in many cases, tablets or capsules given as a “dry swallow” do not pass into the stomach in cats but may become lodged in the esophagus. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach. Denosyl 90 mg tablets are ideal for cats because of their small size. If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denosyl Canine and Feline Daily* Administration Guide

*The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.

Many pets are maintained long-term on every-other-day or every-third-day administration.

Storage

Store in a cool dry place not to exceed 86° F. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.